Atoh7 promotes retinal Müller cell differentiation into retinal ganglion cells
نویسندگان
چکیده
منابع مشابه
Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7.
The specification of the seven retinal cell types from a common pool of retina progenitor cells (RPCs) involves complex interactions between the intrinsic program and the environment. The proneural basic helix-loop-helix (bHLH) transcriptional regulators are key components for the intrinsic programming of RPCs and are essential for the formation of the diverse retinal cell types. However, the e...
متن کاملReprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replaceing Neurod1 with Atoh7
Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replaceing Neurod1 with Atoh7 Chai-An Mao1, Jang-Hyeon Cho1, Jing Wang2, Zhiguang Gao1, Ping Pan1, Wen-Wei Tsai1, Xiuqian Mu3, Laura J. Frishman2 and William H. Klein1 1Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 2College of Optomet...
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Human Müller glia with stem cell characteristics (hMGSCs) have been shown to improve retinal function upon transplantation into rat models of retinal ganglion cell (RGC) depletion. However, their translational potential may depend upon successful engraftment and improvement of retinal function in experimental models with anatomical and functional features resembling those of the human eye. We i...
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PURPOSE To investigate the role of over-expression of Math5 on the retinal ganglion cell (RGC) expression patterns in retinal progenitor cells (RPCs). METHODS RPCs were cultured and then transfected by recombinant Math5 plasmid with internal ribosome entry site and enhanced green fluorescent protein (pIRES2-EGFP-Math5; group A), with pIRES2-EGFP transfected (group B) and no plasmid transfecte...
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ژورنال
عنوان ژورنال: Cytotechnology
سال: 2014
ISSN: 0920-9069,1573-0778
DOI: 10.1007/s10616-014-9777-1